MK-677

Product Description

Quick Specifications

• Content: 20 mg MK-677 per capsule (30 capsules total)
• Form: Research capsules
• Molecular Formula: C₂₇H₃₆N₄O₅S
• Molecular Weight: 528.7 g/mol
• CAS Number: 159634-47-6
• Alternative Names: Ibutamoren, Oratrope, MK-0677, L-163,191
• Purity: >99%

Research Applications & Mechanisms

MK-677 is a powerful, non-peptide compound that mimics ghrelin and triggers growth hormone release. Unlike peptides, this synthetic molecule remains stable in stomach acid and has excellent absorption. It increases both growth hormone (GH) and IGF-1 levels for up to 24 hours after a single dose.

Growth Hormone Research MK-677 activates ghrelin receptors in the brain, causing natural growth hormone release in normal patterns. This avoids the side effects of direct GH injection while providing sustained elevation. Studies show it can restore youthful GH and IGF-1 levels in older subjects without affecting cortisol.

Unlike growth hormone releasing peptides that require injection, MK-677 works and lasts much longer. A single daily dose maintains elevated IGF-1 levels around the clock.

Body Composition Studies Research demonstrates MK-677 helps counteract age-related muscle loss and bone weakness. Two-year human studies show increased body weight (about 2 kg), improved bone density, and better protein retention. The compound helps prevent muscle wasting in bed-ridden patients and during low-protein diets.

MK-677 works best when combined with exercise, helping improve muscle strength, reduce fat mass, and boost bone density. It may help prevent the frailty that comes with aging.

Bone Health Research Studies show MK-677 increases bone formation markers by up to 30% and improves bone-building enzyme levels. In elderly patients with hip fractures, it improved walking speed and reduced falls. The compound increases both bone breakdown and rebuilding, leading to stronger bones when combined with weight training.

Research suggests MK-677 may work well with other growth hormone compounds to maximize bone benefits.

Sleep Enhancement Studies MK-677 produces stronger sleep improvements than other growth hormone compounds. It increases deep sleep (stage 4) by 50% and REM sleep by 20% in young adults. Older adults show even bigger improvements, with REM sleep increasing up to 50%.

Deep sleep is when most tissue repair and muscle recovery happens. Better REM sleep may help with memory and brain function. These sleep benefits make MK-677 valuable for studying how sleep affects health.

Brain Health Applications Research shows IGF-1 helps clear amyloid beta plaques linked to Alzheimer's disease. While MK-677 doesn't help existing Alzheimer's patients, animal studies suggest it may prevent the disease when started early. Mice given MK-677 from a young age showed less brain damage even when genetically prone to Alzheimer's.

The compound may work best as prevention rather than treatment for brain aging.

Cardiovascular Research MK-677 helps restore aging blood vessel stem cells that repair damaged arteries. It also increases nitric oxide production, which helps control blood pressure and prevents heart disease. Studies show it may help prevent atherosclerosis and improve overall heart health.

The compound appears most beneficial for preventing heart problems rather than treating existing disease.

Anti-Aging Applications MK-677 addresses "somatopause" - the natural decline in growth hormone that starts in middle age. By age 70, men produce only 60% of the growth hormone they made at 18. MK-677 can restore more youthful hormone levels and may slow multiple aging processes.

Research suggests the biggest benefits come from long-term use as prevention rather than short-term treatment.

Unique Advantages Unlike SARMs, MK-677 doesn't suppress natural testosterone production and doesn't require cycling on and off. It can be used continuously for extended research periods. The compound's 24-hour duration means once-daily dosing is sufficient.

Storage Instructions Store in a cool, dry place away from direct light and moisture. Keep container tightly sealed. Protect from heat and humidity.

For Research Purposes Only This product is for laboratory research only by qualified scientists. Not for human use, medical treatment, or veterinary applications. Follow all safety protocols.