Product Description

Quick Specifications

• Content: 1,500 mg L-Glutathione per vial
• Form: Sterile lyophilized powder in a glass vial
• Molecular Formula: C₁₀H₁₇N₃O₆S (γ-Glu-Cys-Gly)
• Molecular Weight: 307.33 g/mol
• CAS Number: 70-18-8
• Alternative Names: GSH, Isethion
• Purity: >99%

Research Applications & Mechanisms

L-Glutathione stands as the body's master antioxidant, playing critical roles in cellular defense, detoxification, and metabolic regulation. This tripeptide composed of cysteine, glutamate, and glycine serves as both a direct free-radical scavenger and a cofactor in numerous biochemical pathways essential for cellular health and longevity.

Oxidative Stress & Cellular Protection Research demonstrates glutathione's exceptional capacity to neutralize reactive oxygen species including peroxides, nitrogen dioxide, and hypochlorous acid through direct redox reactions. Beyond its primary antioxidant function, glutathione regenerates other critical antioxidants like vitamins C and E, creating a comprehensive cellular defense network. Studies indicate that glutathione deficiency correlates with accelerated aging and increased disease susceptibility across multiple organ systems.

Neurological Research Applications Investigators studying neurodegenerative processes find glutathione particularly valuable due to its role in preventing ferroptosis—iron-dependent programmed cell death that contributes to Parkinson's disease and cognitive decline. Brain tissue shows the most dramatic age-related glutathione depletion, making supplementation studies critical for understanding neuroprotective mechanisms. Research suggests that maintaining optimal glutathione levels may help preserve cognitive function and motor control during aging.

Immune System Modulation Laboratory studies reveal glutathione's unique immune-regulatory properties, where supplementation shows minimal effect during health but provides substantial benefit during immune challenges. Research indicates that glutathione enhances natural killer cell activity and lymphocyte proliferation, creating a primed immune response. HIV and viral infection studies demonstrate significant improvements in immune function with glutathione administration.

Ocular & Retinal Health Research Glutathione's concentration in retinal tissue and its support of Müller cell function make it essential for vision research. Studies examine its role in maintaining lens protein integrity, preventing cataract formation, and supporting overall retinal health. Research into diabetic retinopathy and age-related macular degeneration frequently incorporates glutathione as a protective factor.

Metabolic & Cardiovascular Applications Beyond antioxidant functions, glutathione serves as a cofactor in nitric oxide cycling and protein folding within the endoplasmic reticulum. Research explores its contributions to endothelial function, blood pressure regulation, and cardiovascular health. Studies also investigate glutathione's role in detoxification pathways, particularly its function in phase II liver conjugation reactions.

Administration & Bioavailability Considerations Research consistently demonstrates that oral glutathione supplementation proves ineffective due to gastrointestinal breakdown. Injectable and inhalation delivery methods show superior bioavailability and therapeutic potential. Studies indicate that direct administration bypasses the synthetic capacity limitations that occur with aging, making it the preferred method for research applications requiring reliable glutathione elevation.

Reconstitution & Storage Reconstitute with bacteriostatic water or sterile saline to desired concentration. Store lyophilized powder at -20°C for maximum stability. Once reconstituted, maintain at 2-8°C and use within 30 days. Protect from light and avoid repeated freeze-thaw cycles.

For Research Purposes Only This product is intended exclusively for laboratory research by qualified investigators. Not for human consumption, therapeutic use, or veterinary applications. All research should be conducted in accordance with institutional guidelines and safety protocols.